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Issue 8, 2016
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Design, synthesis and antiproliferative activity studies of 1,2,3-triazole–chalcones

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Abstract

A series of 1,2,3-triazole–chalcone hybrids were designed, synthesized and evaluated for their antiproliferative activity against three selected cancer cell lines (SK-N-SH, HepG-2 and MGC-803). Most of the synthesized compounds exhibited moderate to good activity against all the cancer cell lines selected. Particularly, compound 12k showed the most excellent antiproliferative activity with an IC50 value of 1.53 μM against SK-N-SH cancer cells. The mechanism studies revealed that compound 12k inhibited the proliferation of SK-N-SH cancer cells by inducing apoptosis and arresting the cell cycle at the G1 phase.

Graphical abstract: Design, synthesis and antiproliferative activity studies of 1,2,3-triazole–chalcones

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Submitted
23 Mar 2016
Accepted
17 Jun 2016
First published
20 Jun 2016

Med. Chem. Commun., 2016,7, 1664-1671
Article type
Research Article

Design, synthesis and antiproliferative activity studies of 1,2,3-triazole–chalcones

D. Fu, S. Zhang, Y. Liu, X. Yue, J. Liu, J. Song, R. Zhao, F. Li, H. Sun, Y. Zhang and H. Liu, Med. Chem. Commun., 2016, 7, 1664
DOI: 10.1039/C6MD00169F

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