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Issue 8, 2016
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The biogenic amine transporter activity of vinylogous amphetamine analogs

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Abstract

A series of vinylogous amphetamine analogs was synthesized and examined for their activity at biogenic amine transporters and serotonin-2 receptor (5-HT2) subtypes. (1S,3E)-1-Methyl-4-phenyl-but-3-enylamine (S-6) is a potent dual dopamine/serotonin (DA/5-HT) releaser with no activity at 5-HT2 receptors. This unique profile of actions suggests that analog S-6 is a viable lead compound for identifying new structural classes of DA/5-HT releasers with therapeutic benefit and reduced abuse liability.

Graphical abstract: The biogenic amine transporter activity of vinylogous amphetamine analogs

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Supplementary files

Article information


Submitted
30 Apr 2016
Accepted
06 Jun 2016
First published
30 Jun 2016

, 2016,7, 1657-1663
Article type
Research Article

The biogenic amine transporter activity of vinylogous amphetamine analogs

A. M. Decker, J. S. Partilla, M. H. Baumann, R. B. Rothman and B. E. Blough, , 2016, 7, 1657
DOI: 10.1039/C6MD00245E

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