Synthesis of amphiphilic, chalcogen-based redox modulators with in vitro cytotoxic activity against cancer cells, macrophages and microbes

Peng Du; Uma M. Viswanathan; Khairan Khairan; Tomislav Buric; Nathaniel E. B. Saidu; Zhanjie Xu; Benjamin Hanf; Inga Bazukyan; Armen Trchounian; Frank Hannemann; Ingolf Bernhardt; Torsten Burkholz; Britta Diesel; Alexandra K. Kiemer; Karl-Herbert Schäfer; Mathias Montenarh; Gilbert Kirsch; Claus Jacob

doi:10.1039/C3MD00204G

Synthesis of amphiphilic, chalcogen-based redox modulators with in vitro cytotoxic activity against cancer cells, macrophages and microbes†

Peng Du,^ab Uma M. Viswanathan,^ac Khairan Khairan,^ah Tomislav Buric,^a Nathaniel E. B. Saidu,^b Zhanjie Xu,^d Benjamin Hanf,^e Inga Bazukyan,^c Armen Trchounian,^c Frank Hannemann,^f Ingolf Bernhardt,^e Torsten Burkholz,^a Britta Diesel,^g Alexandra K. Kiemer,^g Karl-Herbert Schäfer,^h Mathias Montenarh,^b Gilbert Kirsch^d and Claus Jacob*^a

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^a Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, D-66123 Saarbruecken, Germany
E-mail: c.jacob@mx.uni-saarland.de
Fax: +49 681 302 3464
Tel: +49 681 302 3129

^b Division of Medical Biochemistry and Molecular Biology, Saarland University, D-66424 Homburg, Germany

^c Division of Microbiology, Plants and Microbes Biotechnology, Department of Biology, Yerevan State University, 0025 Yerevan, Armenia

^d Laboratoire d'Ingénierie Moléculaire et Biochimie Pharmacologique, SRSMC UMR 7565, Université de Lorraine, 1 Boulevard Arago, 57070 Metz, France

^e Division of Biophysics, Department of Biology, Saarland University, D-66123 Saarbruecken, Germany

^f Division of Biochemistry, Saarland University, D-66123 Saarbruecken, Germany

^g Department of Pharmacy, Saarland University, Pharmaceutical Biology, Saarbruecken, Germany

^h Department of Biotechnology, University of Applied Sciences Kaiserslautern, Zweibruecken, Germany

Abstract

Several amphiphilic, chalcogen-based redox modulators have been synthesized which exhibit a widespread, yet in some instances also selective, biological activity which is most likely based on their ability to modulate the intracellular redox balance and to interact with cellular membranes and specific proteins.

MedChemComm

Synthesis of amphiphilic, chalcogen-based redox modulators with in vitro cytotoxic activity against cancer cells, macrophages and microbes†

Abstract

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Synthesis of amphiphilic, chalcogen-based redox modulators with in vitro cytotoxic activity against cancer cells, macrophages and microbes

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