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Issue 2, 2015
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A pre-structured helix in the intrinsically disordered 4EBP1

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Abstract

The eIF4E–binding protein 1 (4EBP1) has long been known to be completely unstructured without any secondary structures, which contributed significantly to the proposal of the induced fit mechanism for target binding of intrinsically disordered proteins. We show here that 4EBP1 is not completely unstructured, but contains a pre-structured helix.

Graphical abstract: A pre-structured helix in the intrinsically disordered 4EBP1

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Article information


Submitted
05 Sep 2014
Accepted
20 Nov 2014
First published
21 Nov 2014

Mol. BioSyst., 2015,11, 366-369
Article type
Communication

A pre-structured helix in the intrinsically disordered 4EBP1

D. Kim, C. Lee, Y. Cho, S. Lee, E. Cha, J. Lim, T. M. Sabo, C. Griesinger, D. Lee and K. Han, Mol. BioSyst., 2015, 11, 366
DOI: 10.1039/C4MB00532E

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