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Issue 6, 2013
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Ultrafast cell switching for recording cell surface transitions: new insights into epidermal growth factor receptor signalling

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Abstract

A pinched-flow deflection technology was developed for rapid single cell switching between biochemical microenvironments. Millisecond switching was used to stimulate and preserve epidermal growth factor receptor (EGFR) autophosphorylation transitions. Intramolecular phosphorylation initiates signal transduction, is silenced by phosphatase activity until EGFR dimerization enables intermolecular phosphorylation to initiate downstream signalling.

Graphical abstract: Ultrafast cell switching for recording cell surface transitions: new insights into epidermal growth factor receptor signalling

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Supplementary files

Article information


Submitted
23 Nov 2012
Accepted
11 Jan 2013
First published
14 Jan 2013

Lab Chip, 2013,13, 1031-1034
Article type
Communication

Ultrafast cell switching for recording cell surface transitions: new insights into epidermal growth factor receptor signalling

Y. Chiang and J. West, Lab Chip, 2013, 13, 1031
DOI: 10.1039/C3LC41297K

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