Issue 47, 2009
From the journal:

Journal of Materials Chemistry

Self-labeled magneto nanoprobes using tri-aminated polysorbate 80 for detection of human mesenchymal stem cells†

Eun-Kyung Lim,a   Jaemoon Yang,b   Jin-Suck Suh,b   Yong-Min Huh*b  and  Seungjoo Haam*a  

* Corresponding authors

a Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, South Korea
E-mail: haam@yonsei.ac.kr
Fax: +82-2-312-6401
Tel: +82-2-2123-3554

b Department of Radiology, College of Medicine, Yonsei University, Seoul 120-752, South Korea

Abstract

Self-labeled magneto nanoprobes (SLMNs) were synthesized for one-step labeling of human mesenchymal stem cells (hMSCs) via non-invasive magnetic resonance (MR) image tracking. The surface of superparamagnetic nanocrystals (SMNCs) were enveloped by tri-aminated polysorbate 80 (TP80) not only for enhancement of the affinity for hMSCs, but also to achieve increased colloidal stability in the aqueous phase by the nanoemulsion method. The synthesized SLMNs exhibited excellent labeling efficiency of hMSCs and produced highly sensitive MR signals as well as safe cell cytotoxicity.

Graphical abstract: Self-labeled magneto nanoprobes using tri-aminated polysorbate 80 for detection of human mesenchymal stem cells

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Article information

DOI
https://doi.org/10.1039/B912149H
Article type
Paper
Submitted
22 Jun 2009
Accepted
23 Sep 2009
First published
22 Oct 2009

J. Mater. Chem., 2009,19, 8958-8963

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Self-labeled magneto nanoprobes using tri-aminated polysorbate 80 for detection of human mesenchymal stem cells

E. Lim, J. Yang, J. Suh, Y. Huh and S. Haam, J. Mater. Chem., 2009, 19, 8958 DOI: 10.1039/B912149H

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