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Issue 24, 2019
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Identification and characterization of an anthrol reductase from Talaromyces islandicus (Penicillium islandicum) WF-38-12

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Abstract

An NADPH-dependent oxidoreductase from Talaromyces islandicus WF-38-12 has been identified through genome analysis. It has been shown to catalyze a regio- and stereoselective reduction of anthrols (formed in situ by the reduction of anthraquinones in the presence of Na2S2O4) to (R)-dihydroanthracenones, with high enantiomeric excess (>99%). The implications of results on the biosynthesis of deoxygenated (bis)anthraquinones and modified (bis)anthraquinones are discussed.

Graphical abstract: Identification and characterization of an anthrol reductase from Talaromyces islandicus (Penicillium islandicum) WF-38-12

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Supplementary files

Article information


Submitted
31 Aug 2019
Accepted
06 Nov 2019
First published
06 Nov 2019

Green Chem., 2019,21, 6594-6599
Article type
Communication

Identification and characterization of an anthrol reductase from Talaromyces islandicus (Penicillium islandicum) WF-38-12

S. K. Singh, A. Mondal, N. Saha and S. M. Husain, Green Chem., 2019, 21, 6594 DOI: 10.1039/C9GC03072G

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