Issue 24, 2019

Transition metal-free construction of trinuclear N-fused hybrid scaffolds by double nucleophilic aromatic substitution under microwave irradiation

Abstract

Treatment of 2-(2-bromoaryl)- and 2-(2-bromovinyl)benzimidazoles with 2-aminoazoles in the presence of a base under microwave irradiation triggers double C(sp2)–N coupling to form trinuclear N-fused hybrid scaffolds. A reaction pathway involving nucleophilic aromatic substitution (SNAr) accompanied by ammonia evolution is proposed as a key step of this transition metal-free process.

Graphical abstract: Transition metal-free construction of trinuclear N-fused hybrid scaffolds by double nucleophilic aromatic substitution under microwave irradiation

Supplementary files

Article information

Article type
Communication
Submitted
01 Oct 2019
Accepted
11 Nov 2019
First published
12 Nov 2019

Green Chem., 2019,21, 6590-6593

Transition metal-free construction of trinuclear N-fused hybrid scaffolds by double nucleophilic aromatic substitution under microwave irradiation

P. D. Q. Dao, H. Lim and C. S. Cho, Green Chem., 2019, 21, 6590 DOI: 10.1039/C9GC03410B

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