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Issue 16, 2019
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Cascade bio-hydroxylation and dehalogenation for one-pot enantioselective synthesis of optically active β-halohydrins from halohydrocarbons

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Abstract

A stereoselective hydroxylation and enantioselective dehalogenation cascade reaction was developed for the synthesis of optically active β-haloalcohols from halohydrocarbons. This cascade system employed P450 and halohydrin dehalogenase as two compatible biocatalysts, allowing a straightforward, greener and efficient access to β-halohydrins with excellent enantioselectivities (98–99%).

Graphical abstract: Cascade bio-hydroxylation and dehalogenation for one-pot enantioselective synthesis of optically active β-halohydrins from halohydrocarbons

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Publication details

The article was received on 30 May 2019, accepted on 16 Jul 2019 and first published on 17 Jul 2019


Article type: Communication
DOI: 10.1039/C9GC01802F
Green Chem., 2019,21, 4324-4328

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    Cascade bio-hydroxylation and dehalogenation for one-pot enantioselective synthesis of optically active β-halohydrins from halohydrocarbons

    H. Cui, L. Xie, N. Wan, Q. He, Z. Li and Y. Chen, Green Chem., 2019, 21, 4324
    DOI: 10.1039/C9GC01802F

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