Issue 16, 2019

Electrochemical N-acylation synthesis of amides under aqueous conditions

Abstract

An electrochemical N-acylation of carboxylic acids with amines was reported. The sustainable TBAB electrocatalysis proceeded with excellent chemoselectivity and positional selectivity, and with ample scope, allowing electrochemical N-acylation under mild reaction conditions at room temperature in water. Moreover, the synthetic utility of the current method is demonstrated by the synthesis of melatonin.

Graphical abstract: Electrochemical N-acylation synthesis of amides under aqueous conditions

Supplementary files

Article information

Article type
Communication
Submitted
27 Apr 2019
Accepted
18 Jul 2019
First published
19 Jul 2019

Green Chem., 2019,21, 4329-4333

Electrochemical N-acylation synthesis of amides under aqueous conditions

F. Ke, Y. Xu, S. Zhu, X. Lin, C. Lin, S. Zhou and H. Su, Green Chem., 2019, 21, 4329 DOI: 10.1039/C9GC01391A

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