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Issue 4, 2017
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Synthesis of symmetrical pyridines by iron-catalyzed cyclization of ketoxime acetates and aldehydes

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Abstract

A novel and facile iron-catalyzed cyclization of ketoxime acetates and aldehydes for the green synthesis of substituted pyridines has been developed. In the presence of a FeCl3 catalyst, this reaction exhibited a good functional group tolerance to produce 2,4,6-triarylsubstituted symmetrical pyridines in high yields in the absence of any additive. A gram-scale reaction sequence was performed to demonstrate the scaled-up applicability of this synthetic method.

Graphical abstract: Synthesis of symmetrical pyridines by iron-catalyzed cyclization of ketoxime acetates and aldehydes

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Article information


Submitted
14 Nov 2016
Accepted
16 Dec 2016
First published
16 Dec 2016

Green Chem., 2017,19, 1023-1027
Article type
Paper

Synthesis of symmetrical pyridines by iron-catalyzed cyclization of ketoxime acetates and aldehydes

Y. Yi, M. Zhao, Z. Ren, Y. Wang and Z. Guan, Green Chem., 2017, 19, 1023
DOI: 10.1039/C6GC03137D

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