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Issue 4, 2017
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Toward a benign strategy for the manufacturing of betulinic acid

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Abstract

We report a novel and efficient strategy for the preparation of the high-value triterpenoid betulinic acid based on extraction and streamlined oxidation of betulin from the industrial by-product birch bark. The initial extraction of betulin relies on a biphasic system and allowed extracting betulin in short times at room temperature. The crude extract could be directly oxidized, thereby providing a chromium-free, time- and energy saving strategy for the manufacturing of betulinic acid in high yield.

Graphical abstract: Toward a benign strategy for the manufacturing of betulinic acid

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Supplementary files

Article information


Submitted
21 Sep 2016
Accepted
07 Dec 2016
First published
12 Dec 2016

This article is Open Access

Green Chem., 2017,19, 1014-1022
Article type
Paper

Toward a benign strategy for the manufacturing of betulinic acid

A. K. Ressmann, T. Kremsmayr, P. Gaertner, R. Zirbs and K. Bica, Green Chem., 2017, 19, 1014
DOI: 10.1039/C6GC02641A

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