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Issue 11, 2016
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Microwave-assisted direct oxidative synthesis of α-ketoamides from aryl methyl ketones and amines by a water soluble Cu(i)-complex

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Abstract

A stable and isolable bis[(tetrabutylammonium) di-μ-iodo-diiododicuprate(I)] complex has been identified for the direct oxidative synthesis of α-ketoamides from substituted aryl methyl ketones and secondary amines in the presence of molecular oxygen. Gratifyingly, this Cu(I) complex acts as an effective catalytic system with enhanced solubility in both water and organic solvents. These reactions were effectively accelerated by microwave irradiation in water and were applied for the synthesis of a variety of substituted α-ketoamides with good yields. It was interesting to note that, in these optimized microwave reaction times, α-ketoamides were the exclusive products and amide byproducts observed in previous reports were not formed.

Graphical abstract: Microwave-assisted direct oxidative synthesis of α-ketoamides from aryl methyl ketones and amines by a water soluble Cu(i)-complex

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Supplementary files

Article information


Submitted
26 Feb 2016
Accepted
02 Mar 2016
First published
04 Mar 2016

Green Chem., 2016,18, 3439-3447
Article type
Paper

Microwave-assisted direct oxidative synthesis of α-ketoamides from aryl methyl ketones and amines by a water soluble Cu(I)-complex

S. Nekkanti, K. Veeramani, N. Praveen Kumar and N. Shankaraiah, Green Chem., 2016, 18, 3439
DOI: 10.1039/C6GC00557H

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