Catalyst-free synthesis of quinazoline derivatives using low melting sugar–urea–salt mixture as a solvent

Abstract

Low melting mixture of maltose–dimethylurea (DMU)–NH₄Cl was found to be an inexpensive, non-toxic, easily biodegradable and effective reaction medium in the catalyst-free synthesis of quinazoline derivatives. This simple and efficient method furnished the corresponding quinazolines in high yields via one-pot three-component reaction of 2-aminoaryl ketones, aldehyde, and ammonium acetate under aerobic oxidation conditions.