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Issue 30, 2018
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A protein@metal–organic framework nanocomposite for pH-triggered anticancer drug delivery

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Abstract

We have synthesized a core@shell nanocomposite using biocompatible bovine serum albumin (BSA) as the core and a pH-sensitive metal–organic framework (MOF) as the shell. Doxorubicin (DOX)/BSA nanoparticles as cores have been prepared. A zeolitic imidazolate framework-8 (ZIF-8) layer has been coated on the outer surface of the DOX/BSA core. The ZIF layer acts as a capsule for the safe storage of DOX under physiological conditions. An efficient pH-responsive drug delivery system using a BSA/DOX@ZIF, in which the drug is not released in PBS at pH 7.4 but is released at low pH (5.0–6.0), has been constructed. Compared to the pure ZIF, a better biocompatibility has been obtained using the BSA/DOX@ZIF. The BSA/DOX@ZIF shows a much higher efficacy than free DOX against the breast cancer cell line MCF-7. The positive charges on the outer surface of the BSA/DOX@ZIF also improve its cellular uptake.

Graphical abstract: A protein@metal–organic framework nanocomposite for pH-triggered anticancer drug delivery

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Supplementary files

Article information


Submitted
04 May 2018
Accepted
04 Jul 2018
First published
05 Jul 2018

Dalton Trans., 2018,47, 10223-10228
Article type
Paper

A protein@metal–organic framework nanocomposite for pH-triggered anticancer drug delivery

Z. Liang, Z. Yang, H. Yuan, C. Wang, J. Qi, K. Liu, R. Cao and H. Zheng, Dalton Trans., 2018, 47, 10223
DOI: 10.1039/C8DT01789A

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