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Issue 2, 2018
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ROS-mediated carbon monoxide and drug release from drug-conjugated carboxyboranes

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Abstract

Elevated levels of reactive oxygen species (ROS) are associated with several detrimental diseases. Therefore, using this condition for selective treatments could be a great advantage in fighting these disorders. Here, we present amine carboxyboranes as a class of molecules for therapeutic CO gas generation and for delivering drug molecules in the presence of ROS. Our findings indicate amine carboxyboranes to be very slow CO releasers at physiological pH and temperature without any inducers but generate CO faster when reacted with a non-radical ROS (H2O2). Furthermore, a radical ROS (˙OH) dramatically expedites the production of CO from amine carboxyboranes. A decomposition profile shows the release of the amine group during the decarbonylation process from drug-conjugated carboxyboranes. This suggests that the carboxyborane moiety can be a useful tool for the delivery of amine-containing drugs to disease sites which display abundant ROS levels.

Graphical abstract: ROS-mediated carbon monoxide and drug release from drug-conjugated carboxyboranes

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Supplementary files

Article information


Submitted
22 Sep 2017
Accepted
30 Nov 2017
First published
30 Nov 2017

Dalton Trans., 2018,47, 538-543
Article type
Paper

ROS-mediated carbon monoxide and drug release from drug-conjugated carboxyboranes

T. I. Ayudhya, P. J. Pellechia and N. N. Dingra, Dalton Trans., 2018, 47, 538
DOI: 10.1039/C7DT03581K

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