Issue 11, 2013
From the journal:

Chemical Society Reviews

Multivalent glyco(cyclo)peptides†

M. Carmen Galan,a   Pascal Dumyb  and  Olivier Renaudet*bc  

* Corresponding authors

a School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK

b Département de Chimie Moléculaire, UMR-CNRS 5250 & ICMG FR 2607, Université Joseph Fourier, BP 53, 570 rue de la chimie, 38041 Grenoble Cedex 9, France
E-mail: olivier.renaudet@ujf-grenoble.fr
Fax: +33 4 56 52 08 03
Tel: +33 4 56 52 08 33

c Institut Universitaire de France, 103 boulevard Saint-Michel, 75005 Paris, France

Abstract

Because of the importance of carbohydrate–protein interactions in biological processes, the development of glycoclusters and glycodendrimers capable of mimicking the multivalent display of carbohydrates at the cell surface has become a major field of research over the last decade. Among the large variety of scaffolds that are now available, peptides and cyclopeptides are widely used for the multivalent presentation of glycans. This review will provide an overview of the most recent advances in the preparation and utilization of linear glycopeptides and glycocyclopeptides in glycobiology.

Graphical abstract: Multivalent glyco(cyclo)peptides

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Article information

DOI
https://doi.org/10.1039/C2CS35413F
Article type
Tutorial Review
Submitted
08 Oct 2012
First published
21 Dec 2012

Chem. Soc. Rev., 2013,42, 4599-4612

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Multivalent glyco(cyclo)peptides

M. C. Galan, P. Dumy and O. Renaudet, Chem. Soc. Rev., 2013, 42, 4599 DOI: 10.1039/C2CS35413F

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