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Issue 5, 2006
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Heterovalent selectivity and the combinatorial advantage

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Abstract

Libraries of monovalent compounds can be reacted with each other to give libraries of bivalent ones. If those reactions are efficient, and if the products do not need to be purified, large numbers of bivalent compounds can be produced rapidly, and one might say there is a “combinatorial advantage” to doing so. However, selective formation of heterobivalent products must be possible otherwise statistical mixtures will form. This tutorial review describes methods that will give heterobivalent compounds almost exclusively. Although there are relatively few methods that will give that desired selectivity, such methods are becoming increasingly important as the potential applications of bi- and multivalent compounds emerge.

Graphical abstract: Heterovalent selectivity and the combinatorial advantage

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Publication details

The article was received on 24 Nov 2005 and first published on 21 Mar 2006


Article type: Tutorial Review
DOI: 10.1039/B516721N
Chem. Soc. Rev., 2006,35, 416-423

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    Heterovalent selectivity and the combinatorial advantage

    S. J. Reyes and K. Burgess, Chem. Soc. Rev., 2006, 35, 416
    DOI: 10.1039/B516721N

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