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Issue 12, 2011
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The effect of solvent on the catalytic properties of microperoxidase-11

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Abstract

The effect of a range of solvents on the catalytic oxidation of methyl phenyl sulfide to methyl phenyl sulfoxide by MP-11 and by a cyclodextrin derivative of MP-11 was examined. The addition of low concentrations of alcohols enhanced the initial rate of sulfoxidation, most likely due to dispersion of MP-11 aggregates. Higher alcohol concentrations resulted in a decrease in activity arising from solvation of the hydrophobic sulfide, disrupting binding to the catalyst. In alcohols, the yield of product was decreased due to increased rates of MP-11 deactivation via the formation of aldehydes (for primary alcohols) or by peroxide-based deactivation. The catalytic activity of the cyclodextrin modified MP-11 was similar to that of MP-11 itself, demonstrating that it is the N-terminal side of MP-11 which is the determinant of catalytic activity.

Graphical abstract: The effect of solvent on the catalytic properties of microperoxidase-11

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Publication details

The article was received on 29 Oct 2010, accepted on 12 Jan 2011 and first published on 31 Jan 2011


Article type: Paper
DOI: 10.1039/C0CP02321C
Phys. Chem. Chem. Phys., 2011,13, 5304-5313

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    The effect of solvent on the catalytic properties of microperoxidase-11

    N. J. O'Reilly and E. Magner, Phys. Chem. Chem. Phys., 2011, 13, 5304
    DOI: 10.1039/C0CP02321C

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