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Issue 17, 2010
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Lipid coated mesoporous silicananoparticles as photosensitive drug carriers

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Abstract

This paper presents a strategy for the biofunctionalization of novel photosensitizer carriers, mesoporous silica nanoparticles (MSNs). After being calcined and absorbed with photosensitizers (hypocrellin B, HB), MSNs can be coated with a lipid layer. Transmission electron microscopy (TEM) and confocal laser scanning microscopy (CLSM) results proved that HB molecules can be loaded into MSN porous and lipid can coated on the surface of the nanoparticles. When co-cultured with cancer cells (MCF-7), MSNs can transport HB molecules into cells and present low cytotoxicity. With the introduction of a lipid layer, the efficiency of MSN uptake by cells can be improved. These intracellular HB-loaded MSN materials also present cytotoxicity to MCF-7 cells after light irradiation which indicates the materials can be used as good photosensitizer carriers in photodynamic therapy.

Graphical abstract: Lipid coated mesoporous silica nanoparticles as photosensitive drug carriers

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Article information


Submitted
19 Nov 2009
Accepted
28 Jan 2010
First published
24 Feb 2010

Phys. Chem. Chem. Phys., 2010,12, 4418-4422
Article type
Paper

Lipid coated mesoporous silica nanoparticles as photosensitive drug carriers

Y. Yang, W. Song, A. Wang, P. Zhu, J. Fei and J. Li, Phys. Chem. Chem. Phys., 2010, 12, 4418
DOI: 10.1039/B924370D

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