Issue 67, 2020
From the journal:

Chemical Communications

First dual binder of microRNA-146a and monomeric tau: a novel approach for multitargeted therapeutics for neurodegenerative diseases†

Moustafa T. Gabr ORCID logo *a  and  Florent Barbaultb  

* Corresponding authors

a Department of Radiology, Stanford University, Stanford, CA, USA
E-mail: gabr2003@gmail.com

b Universite de Paris, ITODYS, CNRS, UMR 7086, 15 Rue J-A de Baïf, Paris, France

Abstract

We report a new approach for the development of multitargeted therapeutics for Alzheimer's disease (AD) based on dual targeting of monomeric tau and biogenesis of microRNA-146a. Compound MG-1102 displayed a superior neuroprotective activity, in comparison to mono-targeted therapeutics, which validates the likelihood of the success of this approach in AD drug development.

Graphical abstract: First dual binder of microRNA-146a and monomeric tau: a novel approach for multitargeted therapeutics for neurodegenerative diseases

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D0CC04249H
Article type
Communication
Submitted
18 Jun 2020
Accepted
26 Jun 2020
First published
09 Jul 2020

Chem. Commun., 2020,56, 9695-9698

Permissions

Request permissions

First dual binder of microRNA-146a and monomeric tau: a novel approach for multitargeted therapeutics for neurodegenerative diseases

M. T. Gabr and F. Barbault, Chem. Commun., 2020, 56, 9695 DOI: 10.1039/D0CC04249H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements