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A new entry to highly functionalized pyrroles via a cascade reaction of α-amino esters and alkynals

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Abstract

Here, we developed an expedient access route to highly functionalized pyrroles from readily available α-amino acid ester hydrochlorides and alkynals via a cascade condensation/intramolecular cyclization followed by a unique C–N ester migration process. A variety of 1,2,3-trisubstituted pyrroles, which were difficult to acquire with the common methodologies, were successfully prepared in good yields under mild conditions.

Graphical abstract: A new entry to highly functionalized pyrroles via a cascade reaction of α-amino esters and alkynals

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Article information


Submitted
24 Apr 2020
Accepted
13 Jul 2020
First published
13 Jul 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

A new entry to highly functionalized pyrroles via a cascade reaction of α-amino esters and alkynals

L. Wei, S. Xu, Z. Jia, H. Tao and C. Wang, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC02964E

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