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Issue 49, 2020
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Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells

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Abstract

A new dual-targeting polymeric siRNA nanoparticle (Dual-PSNP) was developed via multiple processes: rolling circle transcription, condensation, electrostatic deposition, and click chemistry. The Dual-PSNP showed significantly improved cancer-specific intracellular delivery, gene knockdown efficacy, and apoptosis-mediated cytotoxicity through additive receptor-mediated interactions of the two ligands.

Graphical abstract: Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells

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Supplementary files

Article information


Submitted
10 Mar 2020
Accepted
24 Apr 2020
First published
25 Apr 2020

Chem. Commun., 2020,56, 6624-6627
Article type
Communication

Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells

T. Kim, H. N. Hyun, R. Heo, K. Nam, K. Yang, Y. M. Kim, Y. S. Lee, J. Y. An, J. H. Park, K. Y. Choi and Y. H. Roh, Chem. Commun., 2020, 56, 6624
DOI: 10.1039/D0CC01848A

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