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Issue 82, 2019
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A new chemical approach for proximity labelling of chromatin-associated RNAs and proteins with visible light irradiation

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Abstract

A new nucleus-localized singlet oxygen generator was designed and synthesized. Its capability to label nucleus-localized biomolecules through spatially-restricted oxidation under visible light was validated using fluorescence confocal microscopy. Western blot and RT-qPCR were performed to verify the desirable spatial resolution through enriching chromatin-associated RNAs and proteins.

Graphical abstract: A new chemical approach for proximity labelling of chromatin-associated RNAs and proteins with visible light irradiation

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Publication details

The article was received on 12 Aug 2019, accepted on 17 Sep 2019 and first published on 18 Sep 2019


Article type: Communication
DOI: 10.1039/C9CC06251C
Chem. Commun., 2019,55, 12340-12343

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    A new chemical approach for proximity labelling of chromatin-associated RNAs and proteins with visible light irradiation

    L. Li, J. Liang, H. Luo, K. M. Tam, E. C. M. Tse and Y. Li, Chem. Commun., 2019, 55, 12340
    DOI: 10.1039/C9CC06251C

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