Issue 67, 2019
From the journal:

Chemical Communications

Stereoselective synthesis of 2,5-disubstituted pyrrolidines via gold-catalysed anti-Markovnikov hydroamination-initiated tandem reactions†

Tong-De Tan,a   Yang-Bo Chen,a   Ming-Yang Yang,a   Jia-Le Wang,a   Hao-Ze Su,a   Feng-Lin Hong,a   Jin-Mei Zhoua  and  Long-Wu Ye ORCID logo *ab  

* Corresponding authors

a State Key Laboratory of Physical Chemistry of Solid Surfaces and Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China
E-mail: longwuye@xmu.edu.cn

b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

Abstract

A series of gold-catalysed intramolecular anti-Markovnikov hydroamination-initiated azidation, allylation and heteroarylation reactions of chiral homopropargyl sulfonamides have been developed. Various enantioenriched 2,5-disubstituted pyrrolidines are obtained in moderate to excellent yields with excellent enantioselectivities and generally high diastereoselectivities.

Graphical abstract: Stereoselective synthesis of 2,5-disubstituted pyrrolidines via gold-catalysed anti-Markovnikov hydroamination-initiated tandem reactions

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C9CC05295J
Article type
Communication
Submitted
12 Jul 2019
Accepted
23 Jul 2019
First published
23 Jul 2019

Chem. Commun., 2019,55, 9923-9926

Permissions

Request permissions

Stereoselective synthesis of 2,5-disubstituted pyrrolidines via gold-catalysed anti-Markovnikov hydroamination-initiated tandem reactions

T. Tan, Y. Chen, M. Yang, J. Wang, H. Su, F. Hong, J. Zhou and L. Ye, Chem. Commun., 2019, 55, 9923 DOI: 10.1039/C9CC05295J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements