Highly selective and wash-free visualization of resistant bacteria with a relebactam-derived fluorogenic probe

Yefeng Chen; Minqiu Xu; Weipan Xu; Heng Song; Liqiang Hu; Shuyuan Xue; Shuangzhan Zhang; Xiana Qian; Hexin Xie

doi:10.1039/C9CC04533C

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Highly selective and wash-free visualization of resistant bacteria with a relebactam-derived fluorogenic probe†

Yefeng Chen,‡^a Minqiu Xu,‡^a Weipan Xu,^a Heng Song,^a Liqiang Hu,^a Shuyuan Xue,^a Shuangzhan Zhang,^a Xiana Qian^a and Hexin Xie

*^a

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* Corresponding authors

^a State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
E-mail: xiehexin@ecust.edu.cn

Abstract

Reported herein is a relebactam-derived fluorogenic reagent for covalent labeling of serine β-lactamases (SBLs), which are the major causes of bacterial resistance to β-lactam antibiotics. This highly selective imaging reagent generates over 300-fold stronger near-infrared fluorescence signals upon covalently bonding to SBLs, allowing wash-free visualization of live antimicrobial-resistant bacteria.

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DOI: https://doi.org/10.1039/C9CC04533C
Article type: Communication
Submitted: 13 Jun 2019
Accepted: 12 Jul 2019
First published: 22 Jul 2019

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Chem. Commun., 2019,55, 9919-9922

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Highly selective and wash-free visualization of resistant bacteria with a relebactam-derived fluorogenic probe

Y. Chen, M. Xu, W. Xu, H. Song, L. Hu, S. Xue, S. Zhang, X. Qian and H. Xie, Chem. Commun., 2019, 55, 9919 DOI: 10.1039/C9CC04533C

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Chemical Communications

Highly selective and wash-free visualization of resistant bacteria with a relebactam-derived fluorogenic probe†

Abstract

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Highly selective and wash-free visualization of resistant bacteria with a relebactam-derived fluorogenic probe

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