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Issue 88, 2019
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Targeted covalent inhibition of O-GlcNAc transferase in cells

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Abstract

O-GlcNAc transferase (OGT) glycosylates numerous proteins and is implicated in many diseases. To date, most OGT inhibitors lack either sufficient potency or characterized specificity in cells. We report the first targeted covalent inhibitor that predominantly reacts with OGT but does not affect other functionally similar enzymes. This study provides a new strategy to interrogate cellular OGT functions and to investigate other glycosyltransferases.

Graphical abstract: Targeted covalent inhibition of O-GlcNAc transferase in cells

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Article information


Submitted
14 Jun 2019
Accepted
14 Oct 2019
First published
14 Oct 2019

Chem. Commun., 2019,55, 13291-13294
Article type
Communication

Targeted covalent inhibition of O-GlcNAc transferase in cells

M. Worth, C. Hu, H. Li, D. Fan, A. Estevez, D. Zhu, A. Wang and J. Jiang, Chem. Commun., 2019, 55, 13291
DOI: 10.1039/C9CC04560K

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