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Issue 88, 2019
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Drug orientations within statin-loaded lipoprotein nanoparticles by 19F solid-state NMR

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Abstract

NMR measurements of 19F chemical shift anisotropy and 1H–19F dipolar couplings provide unprecedented information on the molecular orientations of two fluorine-containing statin drugs within the heterogeneous environment of reconstituted high-density lipoprotein (rHDL) nanoparticles, a drug delivery system under clinical investigation.

Graphical abstract: Drug orientations within statin-loaded lipoprotein nanoparticles by 19F solid-state NMR

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Supplementary files

Article information


Submitted
11 Jul 2019
Accepted
14 Oct 2019
First published
14 Oct 2019

This article is Open Access

Chem. Commun., 2019,55, 13287-13290
Article type
Communication

Drug orientations within statin-loaded lipoprotein nanoparticles by 19F solid-state NMR

S. Lau, N. Stanhope, J. Griffin, E. Hughes and D. A. Middleton, Chem. Commun., 2019, 55, 13287
DOI: 10.1039/C9CC05344A

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