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Issue 6, 2019
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A novel tumor and mitochondria dual-targeted photosensitizer showing ultra-efficient photodynamic anticancer activities

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Abstract

We designed and synthesized a simple, but highly effective photosensitizer (G-Mito-Pc), which can precisely target the mitochondria of epidermal growth factor receptor (EGFR)-overexpressing cancer cells, to achieve dual targeting function at both cell and organelle levels in cancer therapy. We further explored the possible molecular mechanism of the enhanced bioactivity of G-Mito-Pc compared to that of the reference photosensitizer using molecular dynamics simulations on their interactions with a physiologically relevant mitochondrial membrane model.

Graphical abstract: A novel tumor and mitochondria dual-targeted photosensitizer showing ultra-efficient photodynamic anticancer activities

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Publication details

The article was received on 28 Nov 2018, accepted on 17 Dec 2018 and first published on 17 Dec 2018


Article type: Communication
DOI: 10.1039/C8CC09456J
Citation: Chem. Commun., 2019,55, 866-869

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    A novel tumor and mitochondria dual-targeted photosensitizer showing ultra-efficient photodynamic anticancer activities

    X. Zhao, Y. Huang, G. Yuan, K. Zuo, Y. Huang, J. Chen, J. Li and J. Xue, Chem. Commun., 2019, 55, 866
    DOI: 10.1039/C8CC09456J

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