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Issue 72, 2018
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Exploring the intramolecular catalysis of the proton exchange process to modulate the relaxivity of Gd(III)-complexes of HP-DO3A-like ligands

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Abstract

The Gd(III)-complexes of three novel HP-DO3A-like ligands have been investigated to assess the relationship between relaxometry and intramolecular catalysis of the proton exchange. The structures of these ligands differ from the parent HP-DO3A because the methyl group of the hydroxy-propyl arm has been replaced by –Ph–OH, –Ph–NH2 and –Ph–COOH, respectively. The phenol, amine and carboxylate functionalities display an intramolecular H-bonding with the coordinated hydroxyl moiety that affects either the pK values of the involved functionalities and the rate of the proton exchange process.

Graphical abstract: Exploring the intramolecular catalysis of the proton exchange process to modulate the relaxivity of Gd(iii)-complexes of HP-DO3A-like ligands

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Publication details

The article was received on 01 Jul 2018, accepted on 10 Aug 2018 and first published on 22 Aug 2018


Article type: Communication
DOI: 10.1039/C8CC05284K
Citation: Chem. Commun., 2018,54, 10056-10059

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    Exploring the intramolecular catalysis of the proton exchange process to modulate the relaxivity of Gd(III)-complexes of HP-DO3A-like ligands

    I. M. Carnovale, M. L. Lolli, S. C. Serra, A. F. Mingo, R. Napolitano, V. Boi, N. Guidolin, L. Lattuada, F. Tedoldi, Z. Baranyai and S. Aime, Chem. Commun., 2018, 54, 10056
    DOI: 10.1039/C8CC05284K

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