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Issue 22, 2018
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The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex trans-[Pt(NH3)2(phenanthridine)Cl]NO3

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Abstract

A trans-DDP based monofunctional phenanthridine Pt(II) complex was synthesized and characterized. Its anticancer activity was studied in vitro on a panel of human cancer cell lines and mouse intestinal cancer organoids. This complex displays significant antitumor properties, with a different spectrum of activity than that of classic bifunctional cross-linking agents like cisplatin.

Graphical abstract: The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex trans-[Pt(NH3)2(phenanthridine)Cl]NO3

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Article information


Submitted
17 Jan 2018
Accepted
14 Feb 2018
First published
27 Feb 2018

This article is Open Access

Chem. Commun., 2018,54, 2788-2791
Article type
Communication

The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex trans-[Pt(NH3)2(phenanthridine)Cl]NO3

W. Zhou, M. Almeqdadi, M. E. Xifaras, I. A. Riddell, Ö. H. Yilmaz and S. J. Lippard, Chem. Commun., 2018, 54, 2788
DOI: 10.1039/C8CC00393A

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