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Issue 22, 2018
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Enhancing anticancer cytotoxicity through bimodal drug delivery from ultrasmall Zr MOF nanoparticles

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Abstract

Dual delivery of dichloroacetate and 5-fluorouracil from Zr MOFs into cancer cells is found to enhance in vitro cytotoxicity. Tuning particle size and, more significantly, surface chemistry, further improves cytotoxicity by promoting caveolae-mediated endocytosis and cytosolic cargo delivery.

Graphical abstract: Enhancing anticancer cytotoxicity through bimodal drug delivery from ultrasmall Zr MOF nanoparticles

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Publication details

The article was received on 20 Dec 2017, accepted on 22 Feb 2018 and first published on 22 Feb 2018


Article type: Communication
DOI: 10.1039/C7CC09739E
Citation: Chem. Commun., 2018,54, 2792-2795
  • Open access: Creative Commons BY license
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    Enhancing anticancer cytotoxicity through bimodal drug delivery from ultrasmall Zr MOF nanoparticles

    I. Abánades Lázaro, S. Abánades Lázaro and R. S. Forgan, Chem. Commun., 2018, 54, 2792
    DOI: 10.1039/C7CC09739E

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