Jump to main content
Jump to site search

Issue 8, 2018
Previous Article Next Article

Catalytic asymmetric formal total syntheses of (+)- and (−)-cycloclavine

Author affiliations

Abstract

We report an expeditious catalytic asymmetric approach to clavine alkaloids via a key Heck cyclization. This reaction sets the formation of vicinal stereocenters with excellent diastereoselectivity. Utilizing the aforementioned strategy, the formal total synthesis of cycloclavine (1) has been achieved via another key late-stage ester-aminolysis of 6.

Graphical abstract: Catalytic asymmetric formal total syntheses of (+)- and (−)-cycloclavine

Back to tab navigation

Supplementary files

Article information


Submitted
24 Nov 2017
Accepted
02 Jan 2018
First published
02 Jan 2018

Chem. Commun., 2018,54, 940-943
Article type
Communication

Catalytic asymmetric formal total syntheses of (+)- and (−)-cycloclavine

S. Chaudhuri, S. Ghosh, S. Bhunia and A. Bisai, Chem. Commun., 2018, 54, 940
DOI: 10.1039/C7CC09045E

Social activity

Search articles by author

Spotlight

Advertisements