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Issue 23, 2017
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Mass spectrometry captures structural intermediates in protein fiber self-assembly

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Abstract

Self-assembling proteins, the basis for a broad range of biological scaffolds, are challenging to study using most structural biology approaches. Here we show that mass spectrometry (MS) in combination with MD simulations captures structural features of short-lived oligomeric intermediates in spider silk formation, providing direct insights into its complex assembly process.

Graphical abstract: Mass spectrometry captures structural intermediates in protein fiber self-assembly

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Publication details

The article was received on 13 Jan 2017, accepted on 01 Feb 2017 and first published on 01 Feb 2017


Article type: Communication
DOI: 10.1039/C7CC00307B
Citation: Chem. Commun., 2017,53, 3319-3322
  • Open access: Creative Commons BY license
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    Mass spectrometry captures structural intermediates in protein fiber self-assembly

    M. Landreh, M. Andersson, E. G. Marklund, Q. Jia, Q. Meng, J. Johansson, C. V. Robinson and A. Rising, Chem. Commun., 2017, 53, 3319
    DOI: 10.1039/C7CC00307B

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