An antimicrobial peptide with an aggregation-induced emission (AIE) luminogen for studying bacterial membrane interactions and antibacterial actions

Ning Ning Li; Jun Zhi Li; Peng Liu; Dicky Pranantyo; Lei Luo; Jiu Cun Chen; En-Tang Kang; Xue Feng Hu; Chang Ming Li; Li Qun Xu

doi:10.1039/C6CC09408B

An antimicrobial peptide with an aggregation-induced emission (AIE) luminogen for studying bacterial membrane interactions and antibacterial actions†

Ning Ning Li,‡^a Jun Zhi Li,‡^a Peng Liu,^b Dicky Pranantyo,^b Lei Luo,^c Jiu Cun Chen,^a En-Tang Kang,^b Xue Feng Hu,*^d Chang Ming Li*^a and Li Qun Xu

*^a

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* Corresponding authors

^a Institute for Clean Energy and Advanced Materials, Faculty of Materials and Energy, Southwest University, Chongqing, China
E-mail: xulq@swu.edu.cn, ecmli@swu.edu.cn

^b Department of Chemical & Biomolecular Engineering, National University of Singapore, Singapore

^c College of Pharmaceutical Science, Southwest University, Chongqing, China

^d National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China
E-mail: huxuefeng@scu.edu.cn

Abstract

A fluorescence technique to investigate the interactions between bacterial membranes and an aggregation-induced emission (AIE) luminogen-decorated AMP (TPE-AMP) was reported. Our simple and fast method consists of mixing TPE-AMP and bacterial suspensions and recording the fluorescence signals by flow cytometry and confocal microscopy in a “non-washing” manner.

Chemical Communications

An antimicrobial peptide with an aggregation-induced emission (AIE) luminogen for studying bacterial membrane interactions and antibacterial actions†

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An antimicrobial peptide with an aggregation-induced emission (AIE) luminogen for studying bacterial membrane interactions and antibacterial actions

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