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Issue 1, 2017
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A Cu(II) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights

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Abstract

A new Cu-based anticancer metallodrug which targets the translocator protein is reported. [CuBr2(TZ6)] elicits a remarkable in vitro cytotoxicity in sensitive and multidrug resistant cell lines and induces a 98% reduction of tumor mass in a murine tumor model. Target binding was studied by experimental and computational methods.

Graphical abstract: A Cu(ii) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights

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Publication details

The article was received on 07 Oct 2016, accepted on 01 Dec 2016 and first published on 01 Dec 2016


Article type: Communication
DOI: 10.1039/C6CC08100B
Citation: Chem. Commun., 2017,53, 134-137

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    A Cu(II) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights

    D. Montagner, B. Fresch, K. Browne, V. Gandin and A. Erxleben, Chem. Commun., 2017, 53, 134
    DOI: 10.1039/C6CC08100B

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