Replication of α-amino acids via Strecker synthesis with amplification and multiplication of chiral intermediate aminonitriles†
Abstract
Replication of chiral L- and D-α-(p-tolyl)glycine has been achieved in combination with the asymmetric induction, amplification and multiplication of their own chiral intermediates, L- and D-aminonitriles, in the solid-phase via the Strecker reaction between three achiral components, which is a plausible prebiotic mechanism for amino acid synthesis.