A H+-triggered bubble-generating nanosystem for killing cancer cells

Lili Yang; Zuhuang Wen; Yijuan Long; Ning Huang; Yuan Cheng; Li Zhao; Huzhi Zheng

doi:10.1039/C6CC04511A

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A H⁺-triggered bubble-generating nanosystem for killing cancer cells†

Lili Yang,^a Zuhuang Wen,^a Yijuan Long,^a Ning Huang,^b Yuan Cheng,^b Li Zhao^c and Huzhi Zheng*^a

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* Corresponding authors

^a Key Laboratory on Luminescent and Real-Time Analytical Chemistry (Southwest University), College of Chemistry and Chemical Engineering, Southwest University, Beibei, Chongqing, China
E-mail: zhenghz@swu.edu.cn

^b Department of Neurosurgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China

^c Southwest University Hospital, Southwest University, Beibei, Chongqing, China

Abstract

We constructed a H⁺-triggered bubble-generating nanosystem (BGNS), which generated CO₂ bubbles in the acidic environment of lysosomes after being internalized by cancer cells. The quickly generated bubbles caused enhanced lysosomal membrane permeabilization. As expected, H⁺-triggered BGNS possessed remarkable cytotoxicity against MCF-7 breast cancer cells, and successfully overcame the multidrug resistance of MCF-7/ADR cells.

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Article information

DOI: https://doi.org/10.1039/C6CC04511A
Article type: Communication
Submitted: 29 May 2016
Accepted: 27 Jul 2016
First published: 28 Jul 2016

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Chem. Commun., 2016,52, 10838-10841

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A H⁺-triggered bubble-generating nanosystem for killing cancer cells

L. Yang, Z. Wen, Y. Long, N. Huang, Y. Cheng, L. Zhao and H. Zheng, Chem. Commun., 2016, 52, 10838 DOI: 10.1039/C6CC04511A

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Chemical Communications