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Issue 24, 2016
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Pharmaceutical nanocrystals confined in porous host systems – interfacial effects and amorphous interphases

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Abstract

DSC and NMR results prove the existence of an amorphous acetaminophen nanolayer between acetaminophen nanocrystals (form I and form III) and pore walls in controlled porous glasses. This nanolayer controls the surface energy. This finding is highly relevant for approaches towards crystal engineering in nanopores and indicates similarities to the situation during the early stages of crystallization in polymorphic bulk samples.

Graphical abstract: Pharmaceutical nanocrystals confined in porous host systems – interfacial effects and amorphous interphases

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Supplementary files

Article information


Submitted
30 Jan 2016
Accepted
23 Feb 2016
First published
23 Feb 2016

Chem. Commun., 2016,52, 4466-4469
Article type
Communication
Author version available

Pharmaceutical nanocrystals confined in porous host systems – interfacial effects and amorphous interphases

N. Sonnenberger, N. Anders, Y. Golitsyn, M. Steinhart, D. Enke, K. Saalwächter and M. Beiner, Chem. Commun., 2016, 52, 4466
DOI: 10.1039/C6CC00962J

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