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Issue 24, 2016
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Isotope effect analyses provide evidence for an altered transition state for RNA 2′-O-transphosphorylation catalyzed by Zn2+

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Abstract

Solvent D2O and 18O kinetic isotope effects on RNA 2′-O-transphosphorylation catalyzed by Zn2+ demonstrate an altered transition state relative to specific base catalysis. A recent model from DFT calculations involving inner sphere coordination to the non-bridging and leaving group oxygens is consistent with the data.

Graphical abstract: Isotope effect analyses provide evidence for an altered transition state for RNA 2′-O-transphosphorylation catalyzed by Zn2+

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Article information


Submitted
11 Dec 2015
Accepted
28 Jan 2016
First published
29 Jan 2016

Chem. Commun., 2016,52, 4462-4465
Article type
Communication
Author version available

Isotope effect analyses provide evidence for an altered transition state for RNA 2′-O-transphosphorylation catalyzed by Zn2+

S. Zhang, H. Gu, H. Chen, E. Strong, E. W. Ollie, D. Kellerman, D. Liang, M. Miyagi, V. E. Anderson, J. A. Piccirilli, D. M. York and M. E. Harris, Chem. Commun., 2016, 52, 4462
DOI: 10.1039/C5CC10212J

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