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Issue 12, 2016
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Synthesis and evaluations of an acid-cleavable, fluorescently labeled nucleotide as a reversible terminator for DNA sequencing

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Abstract

An acid-cleavable linker based on a dimethylketal moiety was synthesized and used to connect a nucleotide with a fluorophore to produce a 3′-OH unblocked nucleotide analogue as an excellent reversible terminator for DNA sequencing by synthesis.

Graphical abstract: Synthesis and evaluations of an acid-cleavable, fluorescently labeled nucleotide as a reversible terminator for DNA sequencing

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Article information


Submitted
20 Nov 2015
Accepted
23 Dec 2015
First published
23 Dec 2015

Chem. Commun., 2016,52, 2549-2552
Article type
Communication

Synthesis and evaluations of an acid-cleavable, fluorescently labeled nucleotide as a reversible terminator for DNA sequencing

L. Tan, Y. Liu, X. Li, X. Wu, B. Gong, Y. Shen and Z. Shao, Chem. Commun., 2016, 52, 2549
DOI: 10.1039/C5CC09578F

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