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Issue 25, 2015
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Target profiling of zerumbone using a novel cell-permeable clickable probe and quantitative chemical proteomics

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Abstract

Zerumbone is a phytochemical with diverse biological activities ranging from anti-inflammatory to anti-cancer properties; however, to date the cellular targets of this important compound have remained elusive. Here we report the global protein target spectrum of zerumbone in living cancer cells using competitive activity-based protein profiling of a novel cell-permeable clickable probe, combined with quantitative mass spectrometry.

Graphical abstract: Target profiling of zerumbone using a novel cell-permeable clickable probe and quantitative chemical proteomics

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Supplementary files

Article information


Submitted
29 Nov 2014
Accepted
09 Jan 2015
First published
09 Jan 2015

Chem. Commun., 2015,51, 5497-5500
Article type
Communication
Author version available

Target profiling of zerumbone using a novel cell-permeable clickable probe and quantitative chemical proteomics

K. A. Kalesh, J. A. Clulow and E. W. Tate, Chem. Commun., 2015, 51, 5497 DOI: 10.1039/C4CC09527H

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