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Issue 89, 2014
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Invasive reaction assisted strand-displacement signal amplification for sensitive DNA detection

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Abstract

A novel DNA detection assay was proposed by invasive reaction coupled with molecular beacon assisted strand-displacement signal amplification (IRASA). Target DNAs are firstly hybridized to two probes to initiate invasive reaction to produce amplified flaps. Then these flaps are further amplified by strand-displacement signal amplification. The detection limit was around 0.2 pM.

Graphical abstract: Invasive reaction assisted strand-displacement signal amplification for sensitive DNA detection

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Publication details

The article was received on 04 Aug 2014, accepted on 10 Sep 2014 and first published on 11 Sep 2014


Article type: Communication
DOI: 10.1039/C4CC06079B
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Chem. Commun., 2014,50, 13722-13724

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    Invasive reaction assisted strand-displacement signal amplification for sensitive DNA detection

    B. Zou, Q. Song, J. Wang, Y. Liu and G. Zhou, Chem. Commun., 2014, 50, 13722
    DOI: 10.1039/C4CC06079B

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