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Issue 46, 2013
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Copper-catalyzed asymmetric 1,4-conjugate addition of Grignard reagents to linear α,β,γ,δ-unsaturated ketones

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Abstract

A highly regioselective and enantioselective copper-catalyzed 1,4-conjugate addition of Grignard reagents to linear α,β,γ,δ-unsaturated ketones was developed. The 1,4-addition products were obtained regioselectively in high yields with up to 98% ee.

Graphical abstract: Copper-catalyzed asymmetric 1,4-conjugate addition of Grignard reagents to linear α,β,γ,δ-unsaturated ketones

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Publication details

The article was received on 22 Mar 2013, accepted on 21 Apr 2013 and first published on 23 Apr 2013


Article type: Communication
DOI: 10.1039/C3CC42088D
Citation: Chem. Commun., 2013,49, 5292-5294

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    Copper-catalyzed asymmetric 1,4-conjugate addition of Grignard reagents to linear α,β,γ,δ-unsaturated ketones

    Z. Ma, F. Xie, H. Yu, Y. Zhang, X. Wu and W. Zhang, Chem. Commun., 2013, 49, 5292
    DOI: 10.1039/C3CC42088D

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