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Issue 11, 2012
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Creation of an artificial metalloprotein with a Hoveyda–Grubbs catalyst moiety through the intrinsic inhibition mechanism of α-chymotrypsin

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Abstract

An L-phenylalanyl chloromethylketone-based inhibitor equipped with a Hoveyda–Grubbs catalyst moiety was regioselectively incorporated into the cleft of α-chymotrypsin through the intrinsic inhibition mechanism of the protein to construct an artificial organometallic protein.

Graphical abstract: Creation of an artificial metalloprotein with a Hoveyda–Grubbs catalyst moiety through the intrinsic inhibition mechanism of α-chymotrypsin

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Publication details

The article was received on 07 Nov 2011, accepted on 06 Dec 2011 and first published on 07 Dec 2011


Article type: Communication
DOI: 10.1039/C2CC16898G
Chem. Commun., 2012,48, 1662-1664

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    Creation of an artificial metalloprotein with a Hoveyda–Grubbs catalyst moiety through the intrinsic inhibition mechanism of α-chymotrypsin

    T. Matsuo, C. Imai, T. Yoshida, T. Saito, T. Hayashi and S. Hirota, Chem. Commun., 2012, 48, 1662
    DOI: 10.1039/C2CC16898G

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