Issue 6, 2012
From the journal:

Chemical Communications

Proteomic profiling and potential cellular target identification of K11777, a clinical cysteine protease inhibitor, in Trypanosoma brucei†

Peng-Yu Yang,a   Min Wang,b   Cynthia Y. Heb  and  Shao Q. Yao*a  

* Corresponding authors

a Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore
E-mail: chmyaosq@nus.edu.sg
Fax: +65 6770169
Tel: +65 65162925

b Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore

Abstract

We report herein the design, synthesis and application of K11777-derived activity-based probes (ABPs) allowing in situ profiling and identification of potential cellular targets of K11777 in Trypanosoma brucei.

Graphical abstract: Proteomic profiling and potential cellular target identification of K11777, a clinical cysteine protease inhibitor, in Trypanosoma brucei

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C1CC16178D
Article type
Communication
Submitted
05 Oct 2011
Accepted
15 Nov 2011
First published
15 Nov 2011

Chem. Commun., 2012,48, 835-837

Permissions

Request permissions

Proteomic profiling and potential cellular target identification of K11777, a clinical cysteine protease inhibitor, in Trypanosoma brucei

P. Yang, M. Wang, C. Y. He and S. Q. Yao, Chem. Commun., 2012, 48, 835 DOI: 10.1039/C1CC16178D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements