Issue 38, 2011
From the journal:

Chemical Communications

Direct spectroscopic evidence for binding of anastrozole to the iron heme of human aromatase. Peering into the mechanism of aromatase inhibition†

Sara Maurelli,a   Mario Chiesa,*a   Elio Giamello,a   Giovanna Di Nardo,b   Valentina E. V. Ferrero,b   Gianfranco Gilardib  and  Sabine Van Doorslaerc  

* Corresponding authors

a Dipartimento di Chimica IFM, Università di Torino and NIS, Nanostructured Interfaces and Surfaces Centre of Excellence, Via P. Giuria 7, I-10125 Torino, Italy
E-mail: m.chiesa@unito.it

b Dipartimento di Biologia Animale e dell'Uomo, Università di Torino, Via Accademia Albertina 13, Torino, Italy

c University of Antwerp, Department of Physics, Universiteitsplein 1, B-2610 Wilrijk-Antwerp, Belgium

Abstract

Aromatase (CYP19A1), is a microsomal cytochrome P450 catalysing the conversion of androgens to estrogens. Non-steroidal inhibitors, such as anastrozole, are important drugs in breast cancer therapy. Using hyperfine sublevel correlation (HYSCORE) spectroscopy we provide the first experimental evidence of the binding of anastrozole to the iron heme of human aromatase.

Graphical abstract: Direct spectroscopic evidence for binding of anastrozole to the iron heme of human aromatase. Peering into the mechanism of aromatase inhibition

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Article information

DOI
https://doi.org/10.1039/C1CC13872C
Article type
Communication
Submitted
29 Jun 2011
Accepted
01 Aug 2011
First published
22 Aug 2011

Chem. Commun., 2011,47, 10737-10739

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Direct spectroscopic evidence for binding of anastrozole to the iron heme of human aromatase. Peering into the mechanism of aromatase inhibition

S. Maurelli, M. Chiesa, E. Giamello, G. Di Nardo, V. E. V. Ferrero, G. Gilardi and S. Van Doorslaer, Chem. Commun., 2011, 47, 10737 DOI: 10.1039/C1CC13872C

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