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Issue 38, 2011
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Direct spectroscopic evidence for binding of anastrozole to the iron heme of human aromatase. Peering into the mechanism of aromatase inhibition

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Abstract

Aromatase (CYP19A1), is a microsomal cytochrome P450 catalysing the conversion of androgens to estrogens. Non-steroidal inhibitors, such as anastrozole, are important drugs in breast cancer therapy. Using hyperfine sublevel correlation (HYSCORE) spectroscopy we provide the first experimental evidence of the binding of anastrozole to the iron heme of human aromatase.

Graphical abstract: Direct spectroscopic evidence for binding of anastrozole to the iron heme of human aromatase. Peering into the mechanism of aromatase inhibition

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Article information


Submitted
29 Jun 2011
Accepted
01 Aug 2011
First published
22 Aug 2011

Chem. Commun., 2011,47, 10737-10739
Article type
Communication

Direct spectroscopic evidence for binding of anastrozole to the iron heme of human aromatase. Peering into the mechanism of aromatase inhibition

S. Maurelli, M. Chiesa, E. Giamello, G. Di Nardo, V. E. V. Ferrero, G. Gilardi and S. Van Doorslaer, Chem. Commun., 2011, 47, 10737
DOI: 10.1039/C1CC13872C

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