Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 3, 2011
Previous Article Next Article

Chemoselective phosphine-catalyzed cascade annulations between two different activated alkenes: highly diastereoselective syntheses of polysubstituted cyclohexanes and cyclopentenes

Author affiliations

Abstract

Chemoselective phosphine-catalyzed cascade [2 + 2 + 2] and [2 + 2 + 1] annulations between two molecules of 2-arylmethylidene cyanoacetates or malononitriles and one molecule of α,β-unsaturated ketones have been developed. Under the nucleophilic catalysis of PPh3 or PBu3 (10 mol%), a highly diastereoselective synthesis of polysubstituted cyclohexanes or cyclopentenes has been successfully achieved, respectively.

Graphical abstract: Chemoselective phosphine-catalyzed cascade annulations between two different activated alkenes: highly diastereoselective syntheses of polysubstituted cyclohexanes and cyclopentenes

Back to tab navigation

Supplementary files

Publication details

The article was received on 26 Jul 2010, accepted on 15 Oct 2010 and first published on 15 Nov 2010


Article type: Communication
DOI: 10.1039/C0CC02817G
Citation: Chem. Commun., 2011,47, 1045-1047

  •   Request permissions

    Chemoselective phosphine-catalyzed cascade annulations between two different activated alkenes: highly diastereoselective syntheses of polysubstituted cyclohexanes and cyclopentenes

    L. Cai, B. Zhang, G. Wu, H. Song and Z. He, Chem. Commun., 2011, 47, 1045
    DOI: 10.1039/C0CC02817G

Search articles by author

Spotlight

Advertisements