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Issue 41, 2008
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The first chemoselective tandem acylation of the Blaise reaction intermediate: a novel method for the synthesis of α-acyl-β-enamino esters, key intermediate for pyrazoles

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Abstract

The Blaise reaction intermediate, a zinc bromide complex of β-enamino ester, could be activated in situ by addition of a stoichiometric or catalytic amount of n-BuLi to allow chemoselective tandem C2-acylation providing α-acyl-β-enamino esters, which are valuable intermediates for the syntheses of tri- and tetrasubstituted pyrazoles.

Graphical abstract: The first chemoselective tandem acylation of the Blaise reaction intermediate: a novel method for the synthesis of α-acyl-β-enamino esters, key intermediate for pyrazoles

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Publication details

The article was received on 01 Aug 2008, accepted on 03 Sep 2008 and first published on 23 Sep 2008


Article type: Communication
DOI: 10.1039/B813369G
Citation: Chem. Commun., 2008,0, 5098-5100

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    The first chemoselective tandem acylation of the Blaise reaction intermediate: a novel method for the synthesis of α-acyl-β-enamino esters, key intermediate for pyrazoles

    Y. Sung Chun, K. Kon Lee, Y. Ok Ko, H. Shin and S. Lee, Chem. Commun., 2008, 0, 5098
    DOI: 10.1039/B813369G

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