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Issue 35, 2008

Metal-free Michael addition initiated multicomponent oxidative cyclodehydration route to polysubstituted pyridines from 1,3-dicarbonyls

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Abstract

A simple metal-free, step-economic and selective access to pyridines from readily available substrates is reported, involving a flexible 4 Å molecular sieves promoted Michael addition initiated domino three-component reaction between a 1,3-dicarbonyl, a Michael acceptor and a synthetic equivalent of ammonia.

Graphical abstract: Metal-free Michael addition initiated multicomponent oxidative cyclodehydration route to polysubstituted pyridines from 1,3-dicarbonyls

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Article information


Submitted
03 Apr 2008
Accepted
19 May 2008
First published
10 Jul 2008

Chem. Commun., 2008, 4207-4209
Article type
Communication

Metal-free Michael addition initiated multicomponent oxidative cyclodehydration route to polysubstituted pyridines from 1,3-dicarbonyls

F. Liéby-Muller, C. Allais, T. Constantieux and J. Rodriguez, Chem. Commun., 2008, 4207 DOI: 10.1039/B805680C

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